The ADAPT Practitioner Training Program enrollment is now open.Learn More

7 Common Hypothyroidism Causes

by

发表于

干燥的皮肤和脱发。冷不耐受。心理雾,认知放缓和痴呆症。体重增加。便秘。不规则的月经和不孕症。痛苦和僵硬的肌肉。萧条。单独使用,这些症状中的任何一个都会造成重大问题 - 但对于甲状腺功能减退的人来说,一些这些症状可以立即出现,使其非常难以呈现正常健康的生活。有效治疗A的第一步thyroid disorder(和eliminating these symptoms) is understanding the root cause of your hypothyroidism.

甲状腺功能亢进ism causes
Identifying the cause of your hypothyroidism is the first step to treating it. iStock/Andrey Shevchuk

Hypothyroidism is quite common, and I see it frequently in my clinical work with patients. People may seek treatment because they’re experiencing some symptoms of hypothyroidism without knowing what’s driving them, or they may have even undergone testing that showed “normal” thyroid function. It’s a frustrating situation to be in: you’re experiencing symptoms, you know something isn’t right, but your doctor hasn’t been able to identify or address the problem.

导致你的甲状腺功能亢进症是什么?查看本文的七种常见原因,并了解如何使用功能药物方法对待它们。#functionalmedicine #wellness #chriskresser.

在常规药物中,甲状腺障碍的护理标准通常不足。他们经常未被诊断,当发现它们时,典型的治疗方法在规定替代激素,而不会调查导致问题的原因。更好的方法是确定甲状腺障碍的根本原因和寻址从你的症状,让你真正的救济。在本文中,我将7个常见的基石ing causes of hypothyroidism and talk about my typical approach in addressing them.

Free eBook

Learn More About Hypothyroidism

甲状腺不平衡可能是您健康问题的来源。下载此免费电子书以了解如何进行智能更改,支持您的甲状腺和缓解症状。

我也讨厌垃圾邮件。你的电子邮件与我安全。通过注册,您同意我们的意见隐私政策

What Is Hypothyroidism?

thyroid, a small but important endocrine gland located in the base of the neck, releases hormones that are involved in the regulation of your metabolism as well as your endocrine, cardiovascular, neurological, and immune function. Every cell in your body has receptors for those hormones, and your thyroid directly acts on your: (1)

  • 心血管系统
  • Gastrointestinal tract
  • Bone metabolism
  • 葡萄糖新陈代谢
  • Body temperature regulation
  • 红细胞新陈代谢
  • Gallbladder and liver function
  • 类固醇激素生产必威星际争霸
  • 脂质和胆固醇代谢
  • Protein metabolism

这就是为什么,如果某些东西与你的甲状腺没有正常工作,你会在你的身体中感受到各种(和破坏性)的症状。

当甲状腺受损时发生甲状腺功能减退症(相反的情况,hyperthyroidism,发生在甲状腺过度活跃并产生过多的甲状腺激素时)。甲状腺激素的生产,转化和摄取过必威星际争霸程非常复杂 - 如果任何一步出错,可能会发生低甲状腺的症状。

虽然我不会进入本文中的完整生产,转换和摄取过程,但这是一些涉及必威星际争霸的关键员工的快速概述:

  • 溶质释放激素(TRH):这种激素在下丘脑中产生,并且它向垂体腺体发出信号,致染色刺激激素(TSH)产生。
  • TSH:Produced by the pituitary gland, TSH stimulates the thyroid to produce the thyroid hormones T4 and T3. Elevated TSH levels could indicate an underfunctioning thyroid. It’s crucial to note that not everyone with hypothyroidism will fit this pattern;lowlevels of TSH can also indicate a problem if coupled with low levels of thyroid hormones.
  • 甲状腺素(T4)和三碘罗酮(T3):甲状腺产生统称为“甲状腺激素”T4和T3。T4,甲状腺激素的无活性形式,必须在身体可以使用之前转换为T3。在我的工作中,我看total T4 and T3(these are bound to a protein carrier and can be circulated in the bloodstream) andfree T4 and T3(these are separated from that carrier and can bind to cell receptors and perform their function).
  • 甲状腺-binding globulin (TBG):TBG is the protein carrier that binds to T4 and T3 and transports those hormones through the blood. Too much TBG can lead to lower levels of free T4 and T3.
  • 甲状腺抗体:在自身免疫情况下,这些抗体攻击并损伤甲状腺。我看着thyroid peroxidase (TPO) antibodies (Ab)thyroglobulin (Tg) Ab。These antibodies can show up years before clinical hypothyroidism develops, making it especially important to spot them early on.

如我所提到的TSH,有几种甲状腺功能亢进的模式,与这些标记的常规视图不一致。For more on those, check out “5不会在标准实验室测试上显示的甲状腺图案。“

Why It’s Important to Understand What’s Causing Your Thyroid Disorder

Functional Medicine,我们总是希望了解慢性疾病的根本原因 - 实际上,那’s the only way to treat it effectively。简单地解决症状是不够的;通常,采取基于症状的治疗方法让人们陷入含有多种药物的人,其中任何一个药物都解决了引起问题的条件。其中一些药物甚至可能对自己的副作用感到不舒服。

对于甲状腺功能减退症的人来说,这尤其如此。If, for example, you’re experiencing亚临床甲状腺功能亢进(意味着您的甲状腺激素水平在常规药物中被认为是常规药物的正常范围内)伴随着体重增加,嗜睡,抑郁和便秘等症状,您可能最终会在没有接收的情况下解决这些问题中的每一个问题任何治疗旨在真实原因:甲状腺障碍。更重要的是,许多可能导致甲状腺功能减退症的问题会影响超过你的甲状腺。例如,肠道脱泻,可能会产生影响on your cardiovascular health, brain function, skin health, and even your risk of developing cancer. Addressing your low thyroid without improving your gut health won’t solve any of those associated issues.

一些潜在的原因也将干扰治疗本身的有效性。炎症是自身免疫的特征,将降低甲状腺受体位点敏感性。这意味着即使是大量的替代剂量甲状腺激素也不会改善具有自身免疫的人的症状,因为他们的细胞无法利用它。在任何治疗可能生效之前,他们需要先解决他们的炎症,从而揭示问题根本原因的重要性。

上面的情况是令人沮丧的,尽管是普通的,一个用于患者和从业者。作为医生,您只想帮助您的患者免受甲状腺障碍的愈合,但不了解根本原因,通常最好的选择是开出替代激素并监测他们的进展。在里面适应从业者培训计划, we teach licensed practitioners how to take a Functional Medicine approach to healthcare by discovering the underlying cause of an illness and addressing it head-on. Our yearlong, virtual course goes in-depth on how to:

  • 解决慢性疾病等甲状腺功能减退症的根本原因。
  • 采用整体,患者以患者为中心的工作方法。
  • 将祖先健康和营养概念整合到您的治疗计划中。
  • Manage your Functional Medicine practice effectively.

这种方法可以拼写患者仍在继续体验问题的患者,尽管他们的甲状腺药物和他们症状的症状和救济症状的人们完全逆转。Click here to find out适应从业者培训计划如何帮助您帮助您的患者。

甲状腺功能减退症的七种常见原因

So what’s causing your low thyroid? Let’s explore seven of the most common reasons that hypothyroidism develops.

1. Autoimmune Thyroiditis, or Hashimoto’s Disease

自身免疫is, by far, the most common cause of hypothyroidism for men and women in the Western world, accounting for around 90 percent of hypothyroidism in adults.2) Autoimmune thyroiditis, orHashimoto’s disease,影响美国每100人中的五个人(并且它在女性中至少八次患有比男性更常见)。(3)在西方世界,Hashimoto’s disease is also a common cause of goiter(在全球其他地区,碘缺乏率通常是罪魁祸首)。

和其他一样autoimmune disorders, Hashimoto’s disease is a case of mistaken identity. The immune system misidentifies the thyroid gland as a foreign pathogen and produces thyroid antibodies to attack it, progressively destroying the thyroid tissue. (4)如您可能猜到的那样,这显着损害了甲状腺功能的能力,导致低水平的甲状腺激素并引起甲状腺功能亢进。

在terestingly, there may also be a connection betweenHelicobacter pylori感染和Hashimoto病。特别毒性的毒株H. pylorihas been found in those with Hashimoto’s disease, and treatment of the infection reduces thyroid autoantibodies. (5)这种应变H. pyloricould trigger thyroid autoimmunity because it shares a very similar genetic sequence with an enzyme involved in thyroid hormone synthesis. This similarity may induce a damaging cross-reaction with thyroid tissue and subsequent autoimmunity.

2.暴露于环境毒素

甲状腺易受损坏的敏感environmental toxins并且可以容易地积累重型金属和毒素,其模仿甲状腺激素结构或含有卤素。那包括:

  • 工业化学品:高氯酸盐,多氯联苯(PCB)和二恶英是普通工业污染物,并已被发现破坏甲状腺功能。(6,7,8)
  • 杀虫剂和除草剂:Pesticides and herbicides can interfere with the thyroid by inhibiting thyroid hormone gene expression, impeding the thyroid’s uptake of iodine, binding to thyroid hormone transport proteins, reducing cellular uptake of thyroid hormone, and increasing thyroid hormone clearance from the body. (9,10.)
  • 消费品中发现的毒素:阻燃剂(在电脑和电视屏幕中发现,家具,地毯填充等),诸如双酚A(BPA)和邻苯二甲酸盐,三胞苷(在手中发现的抗菌化学品),以及来自非棍子的全氟辛酸(PFOA)等增塑剂炊具和耐锈的织物也可以损害你的甲状腺。(11.,12.,13.,14.,15.)
  • Heavy metals:镉,铅,汞和铝可以通过各种机制撞击甲状腺。(16.,17.,18.,19.) Many of these contaminants are increasingly common in our environment due to industrialization and pollution.

Many of these toxins cause outright damage to the thyroid, while others:

  • 在terfere with the production of T4 and T3
  • Reduce available thyroid receptors
  • Hamper the conversion of T4 to T3
  • Cause other problems during the production, conversion, and reuptake process

3.血糖不平衡

Like hypothyroidism,blood sugar disorders非常普遍:(20.,21.,22.)

  • More than 30 million Americans have diabetes.
  • 美国超过8400万人成年人有预先审视。
  • 超过70%的美国成年人超重或肥胖。
  • An estimated one in two Americans may be obese by 2030, and one in four may be “severely obese.”

These statistics are worrying on their own, but they also mean there’s a growing number of people who are at risk for thyroid disorders alongside other major health problems.

The relationship between your thyroid and blood sugar is complex. The thyroid acts on your blood sugar metabolism—so if your thyroid isn’t functioning normally, your blood sugar balance may be out of whack—but your blood sugar also acts on your thyroid. (23.) If you’re experiencing metabolic syndrome, your thyroid function will probably be impacted, as well.

研究表明insulin resistance(common in people with chronically high blood sugar) can increase the destruction of the thyroid in people with Hashimoto’s disease. (24.)Low blood sugar(低血糖)也可以通过抑制垂体腺体的功能(随着我提到的,垂体产生TSH,使您的甲状腺产生T4和T3)来损害甲状腺健康。(25.)

4. Food Intolerance

Gluten intolerance appears to be closely linked with Hashimoto’s disease.许多患有Hashimoto病的人也患有乳糜泻(一种自身免疫病症),无麸质饮食产生甲状腺健康的改善。(26.,27.)为什么这个连接存在?形成麸质的蛋白质部分的胶林蛋白的分子结构与甲状腺的结构非常类似于甲状腺。如果您对麸质敏感而且您消耗它,您的免疫系统将标记胶合蛋白进行破坏 - 并在此过程中攻击您的甲状腺。当您考虑时,这尤其问题:

  • Celiac disease affects 1 to 5 percent of Americans, but many people don’t experience obvious symptoms and may not know they have the condition. (28.,29.)
  • An immune response to gluten can last up to six months after you eat it. (30.)

脱毛食品也会对甲状腺低的人造成问题。Goitrogens are foods that may cause swelling of the thyroid (goiter) by interfering with the gland’s iodine uptake. At low concentrations, you may be able to offset the impact of goitrogens by supplementing with iodine; but a large intake will negatively affect your thyroid. (31.) A partial list of goitrogenic foods includes (for a full list of goitrogens, click here):

  • Cruciferous vegetables like broccoli, cauliflower, cabbage, and bok choy
  • TheRosaceae水果系列,包括樱桃,桃子,覆盆子,草莓和杏子
  • 甜土豆等其他食物,竹笋,大豆和尤卡

5.肠道脱泻

Your gut microbiome is connected to nearly every aspect of your health—including the health and function of your thyroid. Therelationship between your gut and your thyroid深层复杂;肠道的健康会影响你的甲状腺功能,反之亦然

健康的肠道细菌助剂在T4到T3转换过程中,而肠道脱泻症可能会对您的甲状腺代谢产生负面影响。(32.,33.) Your gut and immune system are also closely linked—a permeable intestinal barrier orleaky gutcould play a role in the development of Hashimoto’s disease. (34.)您的甲状腺激素也在肠道屏障中发挥着保护作用,可能有助于预防肠道炎症。(35.,36.)

6.下丘脑 - 垂体 - 肾上腺(HPA)轴功能障碍和应力

The HPA axis (made up of the hypothalamus, pituitary gland, and adrenal glands) is the body’s central stress response system. The HPA axis coordinates the release of cortisol, a hormone that allows our bodies to respond quickly to an immediate threat.Chronic stress, however, can disrupt that process and lead to HPA axis dysfunction.

thyroid is closely tied to the HPA axis. As I mentioned, the hypothalamus produces TRH, which spurs the pituitary to produce TSH, which signals the thyroid to produce T4 and T3. As you might guess, disruptions in the hypothalamus and/or pituitary gland can interfere with that process and impact the thyroid. (37.)

慢性应激促进炎症细胞因子的释放,这减少了下丘脑和垂体腺体的功能(以及甲状腺),抑制甲状腺激素的转化,引起甲状腺激素抗性,并影响适当的其他激素甲状腺功能。(38.,39.,40,41.,42.,43.,44.)改变的细胞因子产生也可以与自身免疫相必威星际争霸关,使HPA轴功能障碍和应力应对关键因素,以考虑哈希米托疾病。(45.)

指出这一点非常重要锻炼太多了也可以破坏HPA轴,并且可能加剧甲状腺功能亢进。过度,强烈的运动是您身体的压力源,它可能会对您的甲状腺健康产生负面影响。

7. Nutrient Deficiencies

您的甲状腺需要特定的营养素能够正确起作用;其中任何一个的缺乏都可以导致甲状腺功能亢进。它们包括:

  • 碘:甲状腺激素含有丰富的碘,碘的缺乏会导致甲状腺功能亢进和甲状腺肿。(46.)在全球范围内,碘缺乏是甲状腺功能亢进最常见的原因。(47.)
  • 锌:Zinc is required for the synthesis of thyroid hormone, and deficiency of zinc has been shown to result in hypothyroidism. (48.)
  • 硒:需要将T4转换为T3。硒缺乏加剧了由碘摄入不足引起的条件。(49.)

There is a unique relationship betweeniodine, selenium, and the thyroid。On one hand, increased iodine intake may worsen an immune attack on the thyroid, making supplemental iodine a poor choice for anyone with Hashimoto’s disease. (50.) On the other hand, when iodine is taken withselenium,我们没有看到同样的自身免疫爆发。(51) It appears that by balancing iodine硒摄入量,我们可以避免那些负面的免疫效果。

甲状腺功能亢进的治疗策略

当涉及治疗任何条件时,我的座右铭一直是使用工作的治疗选择,并导致最小危害 - 或者最好,根本没有伤害。在里面case of hypothyroidism, that often includes implementing dietary and lifestyle changes, potentially alongside supplementation and medication.当然,您最有效的策略将取决于甲状腺障碍的原因。

替代甲状腺激素

在我的工作中,我发现那药物通常需要纠正甲状腺功能亢进。I typically avoid pharmaceuticals where I can, but in situations where they’re effective, they do more good than harm, and there are no non-drug alternatives with the same effect, I will opt for medication. It’s important totake the right thyroid hormone基于导致您的甲状腺功能亢进并解决对问题有所促成的任何其他潜在问题的原因。

Now, thyroid medication alone won’t solve Hashimoto’s disease, gut dysbiosis, blood sugar issues, or any of the other underlying causes I’ve discussed here—and that’s where diet, lifestyle, and supplements can help.

饮食和生活方式干预

有几种dietary changesyou can make that may help your hypothyroidism, such as:

  • 无麸质:如果你有哈希莫病的疾病,我推荐消除饮食中的麸质。不幸的是,如果您对其敏感,则没有“安全金额”。
  • 吃抗炎饮食:An抗炎饮食对患有Hashimoto病的任何人来说都是非常有益的(它也是促进健康的肠道的巨大饮食)。这种饮食免于种子油和精制糖等营养不良的食物,以及可以引发像夜间,鸡蛋,乳制品,谷物和豆类等免疫反应的食物(少数省)。
  • Eating organic:Eating organic produce将帮助您避免像杀虫剂和除草剂等有害毒素。
  • 获得足够的可发酵纤维:Eating foods that are rich in可发酵纤维可以改善你的肠道健康。尝试苹果,柑橘类水果,胡萝卜,洋葱,大蒜,芦笋和绿色香蕉面粉。
  • Reducing intake of goitrogenic foods and preparing them properly:沸腾和蒸汽可以减少食物的养老含量,当然,减少您的摄入量可以减少伤害。
  • Consuming adequate dietary iodine and selenium:在饮食中吃足够的碘和硒是一种避免补充的好方法。海鲜和碘盐是碘的好来源,而巴西坚果是硒的优秀来源。(52)
  • Potentially avoiding a ketogenic diet:非常低的碳水化合物饮食如keto饮食may decrease thyroid function. (53) This is not always the case for everyone, so if you have compelling reasons for going keto, some experimentation may be necessary.

您也可以尝试实施lifestyle changes, like:

  • 管理你的压力:Finding relief from chronic stress can help you alleviate any HPA axis dysfunction that’s driving your thyroid issues. Strategies like yoga,冥想,呼吸练习,和mindfulness可以产生很大的不同。
  • 练习良好的睡眠习惯:睡觉是必不可少的for your overall health as well as a prerequisite for a healthy gut. Aim for around eight hours of sleep each night, settle down in a cool, dark room, and限制你对人造光线的接触
  • 开发可持续运动常规:常规运动is beneficial for your gut health, blood sugar metabolism, and stress management, but it’s important to strike the right balance and not overtrain.
  • 得到足够的太阳:已显示阳光暴露对自身免疫性疾病具有保护作用。(54)
  • 购买高质量的过滤器:反渗透过滤器可以有效地除去像高氯酸盐,农药,PCB,塑料和各种重金属等甲状腺损伤的毒素。
  • Limiting your use of plastics:如果可能的话,不要从塑料容器中喝或储存食物。但是,如果您选择使用一些塑料制品,请查找“无BPA”选项。必威星际争霸请记住,无BPA产品仍可含有其他具有潜在甲状腺破坏效果必威星际争霸的双酚衍生物。
  • Replacing your non-stick cookware:折腾你的不粘炊具并用它替换更好的选择like enamel or stainless steel.

补充

Finally,补充may be what you need to get your thyroid health back on track (and I recommend working with a practitioner to ensure you’re getting the right balance of nutrients). You may need:

  • 碘和硒, if you have a significant deficiency and you’re not able to get enough from your diet
  • Vitamin D,如果你没有得到足够的阳光照射
  • 益生菌,这可以帮助你治愈你的肠道

Get Help for Your Hypothyroidism

The best way to heal from hypothyroidism is by working with a Functional Medicine practitioner who’s prepared to address the root cause of your disorder. It’s crucial that you find someone who can identify what’s really causing your issue, as their treatment plan will vary depending on it. And depending on that cause, your practitioner may also recommend targeted supplementation and/or medication as well as lifestyle changes, like managing your stress levels.

这是它有助于拥有一支专业团队,这些专业人士都致力于帮助您缓解甲状腺功能症状或完全逆转疾病。您的护理团队可能包括:

  • A从业者订购血液工作,规定治疗,并监控您的进度
  • A营养师为了帮助您对饮食进行更改,如除去麸质,采用抗炎饮食,或减少摄入缩醛饮食
  • Ahealth coach在改变习惯时支持你
  • Apersonal trainer为了确保您的健身程序提供您需要的运动,而不会增加压力并恶化您的甲状腺状态
  • A谨慎专家to help you learn how to stay present and manage your stress levels

Now imagine getting at the root cause of your thyroid disorder while having the support of an entire team of professionals who are all focused on helping you. Sounds good, doesn’t it? I believe that this collaborative model and root-cause-based approach is what’s really needed to correct hypothyroidism. That’s why it’s the model we use atAdapt180 Health™

Adapt180 Health™是一个在线,基于会员的健康转型服务,开发出来解决您疾病的根本原因,并为您提供健康。作为成员,您可以访问一个专业团队as well as virtual classes and workshops, guided challenges, and tools to help you make changes and reach your health goals. If you’re looking for help with your thyroid, I encourage you to立即注册
[如果LTE IE IE 8]
[如果LTE IE IE 8]